My personal favorite site is Yahoo Fantasy Football. I think they have the cleanest interface, and one of my favorite features of the site is "Stat Tracker", which allows you to keep score real time, so you can watch the games on TV and at the same time keep up with your team online.

While I like Yahoo's functionality and StatTracker, I think CBSSportsline has the best user interface. Being able to post league stories and have the ticker that gives up to the minute scores within your own league is pretty nice. From a functionality standpoint, you can divide the league into divisions and run divison vs. division numbers competition. I also like the Power Rankings feature.

Having used Yahoo, AOL, ESPN & CBSSportsline, I can tell you, CBSSportsline is the best. Great UI, including lots of ajax calls so you don't have to keep refreshing your page. Of course, all stats are updated in real-time. Just about everything is fully customizable. Live chat on gameday while your watching your scores update this year too.

Check it out for yourself!

ESPN.com

Yahoo! is okay, but its live draft is terrible

I have been using the Yahoo site for years! last night was our draft, and they seemed to have improved some things from last year, such as the user interface, and organization of stats.

Not really into Fantasy football so I can't really answer that one,sorry.