After watching Pacquiao's fight against Hatton last night, I think it would be impossible to believe there is anyone on this planet that could take him on right now. While Mayweather went out as the best pound for pound fighter in the world, I think him taking off time is going to hurt him too much to come back and fight Pacquiao.

I agree, Pacquiao is extremely athletic and lightning fast, and he has been in a couple recent fights against very good opponents, beating them all. I'll also point out Morales, a fighter who defeated Pacquiao on a decision, was knocked out twice by Pacquiao in the two following fights and the poor guy can barely talk anymore.